John Attia ; John P . A . Ioannidis ; Ammarin Thakkinstian ; et al . Are the Results of the Study Valid ? How to Use an Article About Genetic Association : B :
نویسندگان
چکیده
Correction Contact me if this article is corrected. Citations Contact me when this article is cited. This article has been cited 1 time. Topic collections Contact me when new articles are published in these topic areas. Testing/ Therapy; Genetics, Other Neurogenetics; Statistics and Research Methods; Genetics; Genetic Counseling/ Journalology/ Peer Review/ Authorship; Neurology; Alzheimer Disease; Dementias;
منابع مشابه
USERS’ GUIDES TO THE MEDICAL LITERATURE How to Use an Article About Genetic Association A: Background Concepts
A 55-year-old man consults you, worried about his risk of developing Alzheimer disease. His grandfather had dementia in his 70s, and his own father was diagnosed with dementia at 65 years. He has been a smoker since he was 20 years of age, works as an electrician, and has been taking antihypertensive medication (thiazide and !blocker) for the last 5 years. He has never had his cholesterol level...
متن کاملHow to use an article about genetic association: B: Are the results of the study valid?
In the first article of this series, we reviewed the basic genetics concepts necessary to understand genetic association studies. In this second article, we enumerate the major issues in judging the validity of these studies, framed as critical appraisal questions. Was the disease phenotype properly defined and accurately recorded by someone blind to the genetic information? Have any potential ...
متن کاملA: Background Concepts
Correction Contact me if this article is corrected. http://jama.ama-assn.org/cgi/content/full/jama;301/10/1024-b Correction is appended to this PDF and also available at Citations Contact me when this article is cited. This article has been cited 4 times. Topic collections Contact me when new articles are published in these topic areas. Other Neurology; Dementias; Neurogenetics; Genetics; Genet...
متن کاملHow to use an article about genetic association: A: Background concepts.
This is the first in a series of 3 articles serving as an introduction to clinicians wishing to read and critically appraise genetic association studies. We summarize the key concepts in genetics that clinicians must understand to review these studies, including the structure of DNA, transcription and translation, patterns of inheritance, Hardy-Weinberg equilibrium, and linkage disequilibrium. ...
متن کاملHuman Genome Epidemiology (HuGE) Review Association between Apolipoprotein E Polymorphisms and Age-related Macular Degeneration: A HuGE Review and Meta-Analysis
A possible association between apolipoprotein E polymorphisms and age-related macular degeneration has been investigated numerous times, with conflicting results. A previous analysis pooling results from four studies (Schmidt et al., Ophthalmic Genet 2002;23:209–23) suggested an association, but those investigators did not document allele frequencies, the magnitude of the association, or the po...
متن کامل